Sometime in the past Slayback was killed by Deadpool. Ten years later, Slayback returned from the dead and broke into Department K, stealing the Weapon X Program files of Kane and Deadpool. He then tracked down Kane, asking him where Deadpool was. Slayback then took Copycat hostage and tracked Deadpool to Katmandu.
Slayback attacked Deadpool and Copycat, during the fight an A.D.A.M. unit (Zero) became active and destroyed Slayback.